The Geant4 general purpose particle-matter Monte Carlo simulation toolkit is being extended with processes for the modeling of biological damage induced by ionising radiation at the DNA scale. Such developments are on-going in the framework of the Geant4-DNA project. This project was originally initiated by the European Space Agency (ESA). Developments are undertaken by an international collaboration, coordinated since 2008 by the National Institute for Nuclear and Particle Physics (IN2P3) of the National Centre for Scientific Research (CNRS) in France.
Once published, all developments are freely accessible in full open access through the Geant4 toolkit or through our freely accessible Geant4 Virtual Machine.
CENBG microbeam irradiation of a keratinocyte (HaCaT) with alpha particles
see the « microbeam » Geant4 advanced example -
- movie courtesy of L. Garnier (CNRS) -
Irradiation of a pBR322 plasmid, including radiolysis
- movie courtesy of V. Stepan (NPI-ASCR/CENBG/CNRS/IN2P3/ESA) -
On-going developments include
- Physics processes in liquid water and other biological materials
- Physico-chemistry and chemistry processes for water radiolysis
- Molecular geometries
- Quantification of damage (such as single-strand, double-strand breaks, base oxidation...)
Dedicated example applications are provided as well. Please refer to our list of publications and theses for more information.